University of California - MSDS System PAGE 1 05/03/96 Source of MSDS: FISHER SCIENTIFIC CORPORATION MATERIAL SAFETY DATA SHEET ------------------------------------------------------------------------------ FISHER SCIENTIFIC EMERGENCY NUMBER USA: (201) 796-7100 CHEMICAL DIVISION CHEMTREC ASSISTANCE: (800) 424-9300 1 REAGENT LANE CANADA: (613) 226-8874 FAIR LAWN, NJ 07410 ------------------------------------------------------------------------------ SUBSTANCE IDENTIFICATION SUBSTANCE: **ETHYL ALCOHOL, DENATURED** TRADE NAMES/SYNONYMS: ETHANOL, DENATURED; GRAIN ALCOHOL, DENATURED; ETHYL HYDROXIDE, DENATURED; ETHYL HYDRATE, DENATURED; ALGRAIN, DENATURED; ANHYDROL, DENATURED; METHYL CARBINOL, DENATURED; COLOGNE SPIRITS, DENATURED; FERMENTATION ALCOHOL, DENATURED; A-407; CERCLA RATINGS (SCALE 0-3): HEALTH=1 FIRE=3 REACTIVITY=0 PERSISTENCE=0 NFPA RATINGS (SCALE 0-4): HEALTH=2 FIRE=3 REACTIVITY=0 ------------------------------------------------------------------------------ COMPONENTS AND CONTAMINANTS COMPONENT: ETHYL ALCOHOL PERCENT: 85.4-92.2 CAS# 64-17-5 COMPONENT: METHYL ALCOHOL PERCENT: 3.6 CAS# 67-56-1 COMPONENT: METHYL ISOBUTYL KETONE PERCENT: 1.9 CAS# 108-10-1 COMPONENT: ETHYL ACETATE PERCENT: 1.3 CAS# 141-78-6 COMPONENT: TOLUENE PERCENT: 0.8 CAS# 108-88-3 COMPONENT: SOLVENT NAPHTHA PERCENT: 0.72-0.74 CAS# 64742-89-8 COMPONENT: ISOPROPYL ALCOHOL PERCENT: 25 PPM CAS# 67-63-0 COMPONENT: ACETALDEHYDE PERCENT: 10 PPM CAS# 75-07-0 COMPONENT: ACETONE PERCENT: 2 PPM CAS# 67-64-1 COMPONENT: BENZENE PERCENT: <1 PPM CAS# 71-43-2 University of California - MSDS System PAGE 2 05/03/96 COMPONENT: WATER PERCENT: 7.0 EXPOSURE LIMITS: ETHYL ALCOHOL (ETHANOL): 1000 ppm (1880 mg/m3) OSHA TWA 1000 ppm (1880 mg/m3) ACGIH TWA 1000 ppm (1880 mg/m3) NIOSH recommended 10 hour TWA 1000 ppm (1880 mg/m3) DFG MAK TWA; 2000 ppm (3760 mg/m3) DFG MAK 60 minute peak, momentary value, 3 times/shift Measurement method: Charcoal tube; 2-butanol/carbon disulfide; gas chromatography with flame ionization detection; (NIOSH # 1400, Alcohols I). METHYL ALCOHOL (METHANOL): 200 ppm (262 mg/m3) OSHA TWA (skin); 250 ppm (328 mg/m3) OSHA STEL 200 ppm (262 mg/m3) ACGIH TWA (skin); 250 ppm (328 mg/m3) ACGIH STEL 200 ppm (262 mg/m3) NIOSH recommended TWA (skin); 250 ppm (328 mg/m3) NIOSH recommended STEL 200 ppm (262 mg/m3) DFG MAK TWA (skin); 400 ppm (524 mg/m3) DFG MAK 30 minute peak, average value, 4 times/shift Measurement method: Silica gel tube; water; gas chromatography with flame ionization detection; (NIOSH Vol. III # 2000, Methanol). 5000 pounds CERCLA Section 103 Reportable Quantity Subject to SARA Section 313 Annual Toxic Chemical Release Reporting METHYL ISOBUTYL KETONE: 50 ppm (205 mg/m3) OSHA TWA; 75 ppm (307 mg/m3) OSHA STEL 50 ppm (205 mg/m3) ACGIH TWA; 75 ppm (307 mg/m3) ACGIH STEL 50 ppm (205 mg/m3) NIOSH recommended TWA 75 ppm (307 mg/m3) NIOSH recommended STEL 100 ppm (410 mg/m3) DFG MAK TWA; 500 ppm (2050 mg/m3) DFG MAK 30 minute peak, average value, 2 times/shift Measurement method: Charcoal tube; carbon disulfide; gas chromatography with flame ionization detection; (NIOSH Vol. III # 1300, Ketones I). 5000 pounds CERCLA Section 103 Reportable Quantity Subject to SARA Section 313 Annual Toxic Chemical Release Reporting ETHYL ACETATE: 400 ppm (1440 mg/m3) OSHA TWA 400 ppm (1440 mg/m3) ACGIH TWA 400 ppm (1440 mg/m3) NIOSH recommended 10 hour TWA 400 ppm (1440 mg/m3) DFG MAK TWA; 800 ppm (2880 mg/m3) DFG MAK 5 minute peak, momentary value, 8 times/shift Measurement method: Charcoal tube; carbon disulfide; gas chromatography with flame ionization detection; (NIOSH III # S49). 5000 pounds CERCLA Section 103 Reportable Quantity **OSHA revoked the final rule limits of January 19, 1989 in response to the 11th Circuit Court of Appeals decision (AFL-CIO v. OSHA) effective University of California - MSDS System PAGE 3 05/03/96 June 30, 1993. See 29 CFR 1910.1000 (58 FR 35338)** ------------------------------------------------------------------------------ PHYSICAL DATA DESCRIPTION: Clear, colorless liquid. BOILING POINT: >173 F (>78 C) SPECIFIC GRAVITY: not available SOLUBILITY IN WATER: soluble VAPOR DENSITY: 1.6 (ethanol) ------------------------------------------------------------------------------ FIRE AND EXPLOSION DATA FIRE AND EXPLOSION HAZARD: Dangerous fire hazard when exposed to heat or flame. Vapors are heavier than air and may travel a considerable distance to a source of ignition and flash back. Vapor-air mixtures are explosive above flash point. FLASH POINT: >57 F (>14 C) UPPER EXPLOSIVE LIMIT: 19% (ethanol) LOWER EXPLOSIVE LIMIT: 3.3% (ethanol) FLAMMABILITY CLASS(OSHA): IB FIREFIGHTING MEDIA: Dry chemical, carbon dioxide, water spray or alcohol-resistant foam (1993 Emergency Response Guidebook, RSPA P 5800.6). For larger fires, use water spray, fog or alcohol-resistant foam (1993 Emergency Response Guidebook, RSPA P 5800.6). FIREFIGHTING: Move container from fire area if you can do it without risk. Dike fire-control water for later disposal; do not scatter the material. Apply cooling water to sides of containers that are exposed to flames until well after fire is out. Stay away from ends of tanks. Withdraw immediately in case of rising sound from venting safety device or any discoloration of tank due to fire. Isolate for 1/2 mile in all directions if tank, rail car or tank truck is involved in fire (1993 Emergency Response Guidebook, RSPA P 5800.6, Guide Page 28). Extinguish only if flow can be stopped. Use flooding amounts of water as a fog; solid streams may be ineffective. Cool containers with flooding amounts of water from as far a distance as possible. Avoid breathing poisonous vapors, keep upwind. ------------------------------------------------------------------------------ TRANSPORTATION DATA U.S. DEPARTMENT OF TRANSPORTATION SHIPPING NAME-ID NUMBER, 49 CFR 172.101: Denatured alcohol-NA 1987 U.S. DEPARTMENT OF TRANSPORTATION HAZARD CLASS OR DIVISION, 49 CFR 172.101: 3 - Flammable liquid University of California - MSDS System PAGE 4 05/03/96 U.S. DEPARTMENT OF TRANSPORTATION PACKING GROUP, 49 CFR 172.101: PG II U.S. DEPARTMENT OF TRANSPORTATION LABELING REQUIREMENTS, 49 CFR 172.101 AND SUBPART E: Flammable liquid U.S. DEPARTMENT OF TRANSPORTATION PACKAGING AUTHORIZATIONS: EXCEPTIONS: 49 CFR 173.150 NON-BULK PACKAGING: 49 CFR 173.202 BULK PACKAGING: 49 CFR 173.242 U.S. DEPARTMENT OF TRANSPORTATION QUANTITY LIMITATIONS 49 CFR 172.101: PASSENGER AIRCRAFT OR RAILCAR: 5 L CARGO AIRCRAFT ONLY: 60 L ------------------------------------------------------------------------------ TOXICITY ETHYL ALCOHOL (ETHANOL): IRRITATION DATA: 400 mg open skin-rabbit mild; 20 mg/24 hours skin-rabbit moderate; 500 mg/24 hours eye-rabbit mild; 500 mg eye-rabbit severe; 100 mg/4 seconds rinsed eye-rabbit moderate. TOXICITY DATA: 20000 ppm/10 hours inhalation-rat LC50; 39 gm/m3/4 hours inhalation-mouse LC50; 21900 ppm inhalation-guinea pig LCLo; 20 gm/kg skin-rabbit LDLo; 700 mg/kg oral-man TDLo; 2 gm/kg oral-child LDLo; 14400 mg/kg/30 minutes intermittent oral-child TDLo; 50 mg/kg oral-man TDLo; 1430 ug/kg oral-man TDLo; 256 gm/kg/12 weeks oral-woman TDLo; 1400 mg/kg oral-human LDLo; 7060 mg/kg oral-rat LD50; 3450 mg/kg oral-mouse LD50; 6 gm/kg oral-cat LDLo; 5500 mg/kg oral-dog LDLo; 6300 mg/kg oral-rabbit LD50; 5560 mg/kg oral-guinea pig LD50; 19 gm/kg/21 days-continuous oral-rat TDLo; 19440 mg/kg subcutaneous-infant LDLo; 8285 mg/kg subcutaneous-mouse LD50; 6 gm/kg subcutaneous-dog LDL0; 20 gm/kg subcutaneous-rabbit LDLo; 2374 mg/kg intravenous-rabbit LD50; 1600 mg/kg intravenous-dog LDLo; 1440 mg/kg intravenous-rat LD50; 3945 mg/kg intravenous-cat LDLo; 1973 mg/kg intravenous-mouse LD50; 4300 mg/kg intraperitoneal-mammal LD50; 3 gm/kg intraperitoneal-dog LDLo; 3600 ug/kg intraperitoneal-rat LD50; 933 mg/kg intraperitoneal-mouse LD50; 963 mg/kg intraperitoneal-rabbit LD50; 5068 mg/kg intraperitoneal-hamster LD50; 3414 mg/kg intraperitoneal-guinea pig LD50; 11 mg/kg intraarterial-rat LD50; 36 gm/kg parenteral-frog LDLo; mutagenic data (RTECS); reproductive effects data (RTECS); tumorigenic data (RTECS). CARCINOGEN STATUS: None. Human Sufficient Evidence (IARC Group-1 for alcoholic beverages). Animal Inadequate Evidence for the carcinogenicity of ethanol and alcoholic beverages in experimental animals. LOCAL EFFECTS: Irritant- inhalation, skin, eye. ACUTE TOXICITY LEVEL: Slightly toxic by inhalation and ingestion. TARGET EFFECTS: Central nervous system depressant; hepatotoxin. AT INCREASED RISK FROM EXPOSURE: Persons with liver disease, epilepsy or renal impairment. ADDITIONAL DATA: Allergic reactions to alcohols have been reported. May cross the placenta and be excreted in breast milk. METHYL ALCOHOL (METHANOL): IRRITATION DATA: 20 mg/24 hours skin-rabbit moderate; 40 mg eye-rabbit moderate; 100 mg/24 hours eye-rabbit moderate. University of California - MSDS System PAGE 5 05/03/96 TOXICITY DATA: 86000 mg/m3 inhalation-human TCLo; 300 ppm inhalation-human TCLo; 64000 ppm/4 hours inhalation-rat LC50; 1000 ppm inhalation-monkey LCLo; 50 gm/m3/2 hours inhalation-mouse LCLo; 44 gm/m3/6 hours inhalation-cat LCLo; 50 mg/m3/12 hours/13 weeks-intermittent inhalation-rat TCLo; 15800 mg/kg skin-rabbit LD50; 393 mg/kg skin-monkey LDLo; 428 mg/kg oral-human LDLo; 143 mg/kg oral-human LDLo; 6422 mg/kg oral-man LDLo; 3429 mg/kg oral-man TDLo; 4 gm/kg oral-woman TDLo; 7 gm/kg oral-monkey LD50; 5628 mg/kg oral-rat LD50; 7300 mg/kg oral-mouse LD50; 14200 mg/kg oral-rabbit LD50; 7500 mg/kg oral-dog LDLo; 9800 mg/kg subcutaneous-mouse LD50; 2131 mg/kg intravenous-rat LD50; 4710 mg/kg intravenous-mouse LD50; 8907 mg/kg intravenous-rabbit LD50; 4641 mg/kg intravenous-cat LDLo; 7529 mg/kg intraperitoneal-rat LD50; 10765 mg/kg intraperitoneal-mouse LD50; 1826 mg/kg intraperitoneal-rabbit LD50; 3556 mg/kg intraperitoneal-guinea pig LD50; 8555 mg/kg intraperitoneal-hamster LD50; 868 mg/kg unreported-man LDLo; mutagenic data (RTECS); reproductive effects data (RTECS). CARCINOGEN STATUS: None. LOCAL EFFECTS: Irritant- skin, eye. ACUTE TOXICITY LEVEL: Slightly toxic by dermal absorption and ingestion; relatively non-toxic by inhalation. TARGET EFFECTS: Central nervous system depressant; neurotoxin. AT INCREASED RISK FROM EXPOSURE: Persons with kidney, eye or skin disorders. ADDITIONAL DATA: May cause blindness. METHYL ISOBUTYL KETONE: IRRITATION DATA: 500 mg/24 hours skin-rabbit mild; 200 ppm/15 minutes eye-human; 40 mg eye-rabbit severe; 500 mg/24 hours eye-rabbit mild. TOXICITY DATA: 23300 mg/m3 inhalation-mouse LC50; 4000 ppm inhalation-rat LCLo; 1996 ppm/6 hours/11 days-intermittent inhalation-rat TCLo; 1002 ppm/6 hours/14 weeks-intermittent inhalation-rat TCLo; 1996 ppm/6 hours/11 days-intermittent inhalation-mouse TCLo; 1002 ppm/6 hours/14 weeks-intermittent inhalation-mouse TCLo; >20 gm/kg skin-rabbit LD50; 35700 ppm/6 hours/17 weeks-intermittent skin-rat TDLo; 2080 mg/kg oral-rat LD50; 2671 mg/kg oral-mouse LD50; 1600 mg/kg oral-guinea pig LD50; 400 mg/kg intraperitoneal-rat LD50; 268 mg/kg intraperitoneal-mouse LD50; 800 mg/kg intraperitoneal-guinea pig LD50; 1396 mg/kg unreported-mammal LD50; reproductive effects data (RTECS). CARCINOGEN STATUS: None. LOCAL EFFECTS: Irritant- inhalation, skin, eye. ACUTE TOXICITY LEVEL: Moderately toxic by inhalation and ingestion; relatively non-toxic by dermal absorption. TARGET EFFECTS: Central nervous system depressant. Poisoning may affect the liver and kidneys. AT INCREASED RISK FROM EXPOSURE: Persons with pre-existing eye or skin disorders, or impaired liver, kidney, or respiratory function. ADDITIONAL DATA: Alcohol may enhance the toxic effects. ETHYL ACETATE: IRRITATION DATA: 400 ppm eye-human. TOXICITY DATA: 400 ppm inhalation-human TCLo; 200 gm/m3 inhalation-rat LC50; 45 gm/m3/2 hours inhalation-mouse LC50; 61 gm/m3 inhalation-cat LCLo; >20 gm/kg skin-rabbit LD50; 5620 mg/kg oral-rat LD50; 4100 mg/kg oral-mouse LD50; 4935 mg/kg oral-rabbit LD50; 5500 mg/kg oral-guinea pig LD50; 5 gm/kg subcutaneous-rat LDLo; 3 gm/kg subcutaneous-guinea pig LD50; 3 gm/kg subcutaneous-cat LD50; 709 mg/kg intraperitoneal-mouse LD50; mutagenic data (RTECS). CARCINOGEN STATUS: None. University of California - MSDS System PAGE 6 05/03/96 LOCAL EFFECTS: Irritant- inhalation, skin, eye. ACUTE TOXICITY LEVEL: Slightly toxic by inhalation, dermal absorption, and ingestion. TARGET EFFECTS: Central nervous system depressant. Poisoning may also affect the liver and kidneys. AT INCREASED RISK FROM EXPOSURE: Persons with chronic respiratory disease, skin disease or anemia. ------------------------------------------------------------------------------ HEALTH EFFECTS AND FIRST AID INHALATION: ETHYL ALCOHOL (ETHANOL): IRRITANT/NARCOTIC. ACUTE EXPOSURE- Exposure of humans to 1000-10,000 ppm has caused temporary irritation of the upper respiratory tract and coughing; and if continued, central nervous system depression with headache, stupor, fatigue, dizziness, drowsiness, dullness, lassitude and loss of appetite may occur. A level of 20,000 ppm was considered just tolerable, and above this level, the atmosphere was described as intolerable and suffocating on even brief exposures. Additionally, exposure of animals to various concentrations has resulted in excitation followed by ataxia, incoordination, prostration, twitching, general paralysis, dyspnea, and occasionally death due to respiratory failure. CHRONIC EXPOSURE- Repeated or prolonged inhalation of vapors may cause irritation of the mucous membranes, headache, dizziness, nervousness, tremors, fatigue, nausea, narcosis, lack of concentration, and somnolence. Tolerance may be a factor in individual response to a given air concentration. Reproductive effects have been reported in animals. METHYL ALCOHOL (METHANOL): NARCOTIC/NEUROTOXIN. 25,000 ppm Immediately Dangerous to Life or Health. ACUTE EXPOSURE- May cause irritation of the mucous membranes, coughing, oppression in the chest, tracheitis, bronchitis, tinnitus, unsteady gait, twitching, colic, constipation, nystagmus, and blepharospasm. Symptoms from occupational exposure include paresthesias, numbness and shooting pains in the hands and forearms. Metabolic acidosis, and effects on the eyes and central nervous system may occur as detailed in acute ingestion. CHRONIC EXPOSURE- Repeated or prolonged exposure may cause effects as in acute ingestion. Repeated exposure to 200-375 ppm caused recurrent headaches in workers. Exposure for 4 years to 1200-8000 ppm resulted in marked diminution of vision and enlargement of the liver in a workman. Reproductive effects have been reported in animals. METHYL ISOBUTYL KETONE: IRRITANT/NARCOTIC. 3000 ppm Immediately Dangerous to Life or Health. ACUTE EXPOSURE- Vapor concentrations of 100 ppm may cause headache and nausea. Exposure to 200 ppm may be irritating to the respiratory tract. Exposure to concentrations >50 ppm may cause gastrointestinal effects such as nausea, vomiting, loss of appetite and diarrhea. Higher levels may cause central nervous system depression with lightheadedness, dizziness, dullness, incoordination, ataxia, unconsciousness, coma and death. Exposure of rats to 4000 ppm/4 hours caused death while 2000 ppm/ 4 hours was not lethal. Fatty livers and congestion of the brain, lungs University of California - MSDS System PAGE 7 05/03/96 and spleen were noted in animals dying after exposure to 28000 ppm/45 minutes. CHRONIC EXPOSURE- Workers exposed to 80-500 ppm for 30 minutes per day complained of throat irritation, weakness, loss of appetite, headache, nausea, and vomiting. A few workers experienced insomnia, somnolence, heartburn, intestinal pain and slight liver enlargement. Exposure of rats to 100 ppm/90 days resulted in heavier livers and kidneys with reversible nephrosis of the kidneys. Exposure of rats to 20-30 ppm/4 hours/day for 4 and 1/2 months caused disturbances in conditioned reflexes, interference with detoxifying function of the liver and elevated eosinophil count. Minimal distal axonal changes resulted from exposure to 1500 ppm for 5 months. Exposure of pregnant rats and mice to 3000 ppm produced a significant decrease in fetal body weight and retardation of skeletal ossification in the fetuses. ETHYL ACETATE: IRRITANT/NARCOTIC. 2000 ppm Immediately Dangerous to Life or Health. ACUTE EXPOSURE- Inhalation of 400 ppm for 3-5 minutes has caused respiratory tract irritation in humans. Low vapor concentrations may also cause headache, coughing, dizziness, drowsiness, and shortness of breath. High concentrations may cause narcotic effects with anesthesia and unconsciousness and renal and hepatic damage. Pathologic findings have included marked hyperemia of the respiratory tract, pulmonary edema, hemorrhagic gastritis, and hyperemia of the spleen and kidneys. CHRONIC EXPOSURE- No adverse symptoms were observed in workers exposed to 375-1500 ppm for several months. Animal studies indicate that 4450 ppm for 1 hour daily for 40 days caused secondary anemia, leukocytosis, and liver and kidney damage. A 10-day vapor inhalation study in rats resulted in decreased motor activity and affects in breathing rates when exposed to >3000 ppm. In rare instances, repeated exposure may result in sensitization with mucous membrane irritation and eczematous eruptions. FIRST AID- Remove from exposure area to fresh air immediately. Perform artificial respiration if necessary. Keep person warm and at rest. Treat symptomatically and supportively. Get medical attention immediately. SKIN CONTACT: ETHYL ALCOHOL (ETHANOL): IRRITANT. ACUTE EXPOSURE- Direct contact may cause mild redness and burning. Sensitization has occasionally been reported to occur in some individuals resulting in allergic contact dermatitis in the form of eczematous eruptions or, rarely, erythematous flush or contact urticaria at the exposed site. Animal studies indicate that, depending on concentration and duration of exposure, varying degrees of irritation may occur ranging from mild to severe. Skin absorption may also occur. CHRONIC EXPOSURE- Repeated or prolonged contact with the liquid can cause defatting of the skin, producing a dry, fissured dermatitis, or other symptoms as in acute exposure. A 21-day modified Draize open test study resulted in no irritation in men, whereas an occlusive test resulted in erythema and induration toward the end of the exposure period. METHYL ALCOHOL (METHANOL): IRRITANT/NARCOTIC/NEUROTOXIN. ACUTE EXPOSURE- Contact with liquid may cause irritation. Skin absorption may occur and cause metabolic acidosis and effects on the eyes and central University of California - MSDS System PAGE 8 05/03/96 nervous system as detailed in acute ingestion. CHRONIC EXPOSURE- Repeated or prolonged contact with the liquid may cause defatting of the skin resulting in erythema, scaling, and eczematoid dermatitis. Chronic absorption may result in metabolic acidosis and effects as detailed in acute ingestion. METHYL ISOBUTYL KETONE: IRRITANT. ACUTE EXPOSURE- Vapor may cause irritation with redness. 500 mg applied to rabbit skin produced moderate irritation with transient erythema. CHRONIC EXPOSURE- Repeated or prolonged skin contact may cause defatting of the skin with primary irritation and desquamation. Exposure to vapor concentrations of 80-500 ppm has also been reported to cause dermatitis. ETHYL ACETATE: IRRITANT. ACUTE EXPOSURE- Direct contact with the liquid may cause irritation with redness and defatting action on the skin. CHRONIC EXPOSURE- Repeated or prolonged exposure may cause defatting dermatitis. In rare instances, repeated exposure may result in sensitization with eczematous eruptions. FIRST AID- Remove contaminated clothing and shoes immediately. Wash with soap or mild detergent and large amounts of water until no evidence of chemical remains (at least 15-20 minutes). Get medical attention immediately. EYE CONTACT: ETHYL ALCOHOL (ETHANOL): IRRITANT. ACUTE EXPOSURE- Vapor concentrations of 1,000-10,000 ppm may cause temporary eye irritation, with 15,000 ppm causing continuous tearing. Direct contact with the liquid may cause immediate burning and stinging, with reflex closure of the lids, tearing, temporary injury of the corneal epithelium, and hyperemia of the conjunctiva. Healing is usually spontaneous and complete. Depending on the concentration, contact with rabbit eyes causes a response ranging from mild irritation to severe injury. Irrigation of rabbit eyes with a 10% solution for several minutes caused no serious disturbances. CHRONIC EXPOSURE- Repeated application to rabbit eyes of 40-80% solutions caused corneal cloudiness, conjunctival necrosis, and loss of corneal epithelium and endothelium, followed by conjunctival hemorrhaging and edema, and infiltration and vascularization of the corneal stroma. METHYL ALCOHOL (METHANOL): IRRITANT. ACUTE EXPOSURE- Vapors may cause irritation. High concentrations have been reported to cause violent inflammation of the conjunctiva and epithelial defects on the cornea. Mild irritation may occur with dilute solutions; the undiluted liquid has produced moderate corneal opacity and conjunctival redness in rabbits. Application of a drop of methanol in rabbit eyes caused a mild reversible reaction, graded 3 on a scale of 1-10 after 24 hours. CHRONIC EXPOSURE- Repeated or prolonged contact may cause conjunctivitis. METHYL ISOBUTYL KETONE: University of California - MSDS System PAGE 9 05/03/96 IRRITANT. ACUTE EXPOSURE- Vapor concentrations of 200 ppm are irritating to the eyes. Direct contact with liquid may cause pain and irritation. Exposure of >1000 ppm to guinea pigs caused severe irritation with lacrimation. CHRONIC EXPOSURE- Repeated or prolonged contact with irritants may cause conjunctivitis. ETHYL ACETATE: IRRITANT. ACUTE EXPOSURE- Direct contact with the liquid may cause irritation, with redness, pain, and lacrimation. Exposure to 400 ppm may cause a sensation of irritation in humans. Application of 2 drops to rabbit corneas, followed 2 minutes later by rinsing with water, caused immediate fine optical irregularity of the corneal epithelium, which returned to normal in 2 days. CHRONIC EXPOSURE- Repeated or prolonged exposure may cause conjunctivitis and cornea clouding. Rabbits exposed to the vapor at levels which would be scarcely tolerable to humans caused no corneal damage despite being exposed for 8 hours/day for 5 days/week for up to 7 weeks. FIRST AID- Wash eyes immediately with large amounts of water or normal saline, occasionally lifting upper and lower lids, until no evidence of chemical remains (at least 15-20 minutes). Get medical attention immediately. INGESTION: ETHYL ALCOHOL (ETHANOL): NARCOTIC/HEPATOTOXIN. ACUTE EXPOSURE- Ingestion may cause emotional lability and decreased inhibitions, with exhilaration, boastfulness, talkativeness, remorse, and belligerency; followed by gradual visual impairment, muscular incoordination, slowing of reaction time, sensory disturbances, and slurring of speech. Other symptoms may include flushing of the face, dilated pupils, rapid pulse, nausea, vomiting, sweating, and diuresis. Ingestion of large amounts may cause confusion, disorientation, loss of motor nerve control, shallow respiration, involuntary defecation and urination, drowsiness, stupor, and possibly coma. Convulsions due to hypoglycemia and shock with hypotension, tachycardia, cold pale skin, hypothermia, respiratory depression, and decreased reflexes may occur. Death may occur from respiratory or circulatory failure or later from aspiration pneumonitis or pulmonary edema. Recovery may be accompanied by headache, insomnia, gastritis, infection, restlessness, psychoses with uncontrollable fear, and visual, auditory, or gustatory hallucinations, exaggerated reflexes, tachycardia, and convulsions. Some individuals sensitized by external contact may suffer from a generalized erythema, stomatitis, urticaria, angioedema, morbilliform eruptions, or eczematous dermatitis at sites previously affected by external contact. Reproductive effects have been reported in animals. CHRONIC EXPOSURE- Chronic intoxication may result in weight loss, degenerative changes in the liver, kidneys, and brain, gastroenteritis with anorexia and diarrhea, and cirrhosis of the liver. Polyneuritis with pain, motor and sensory loss in the extremities, and optic atrophy may occur. Amnesia, tremors, confusion, impaired judgement, and loss or impairment of mental abilities are possible. Many years of chronic ingestion have caused acute myopathy with tenderness, aching, edema, and degeneration of the muscles. The heart may be affected, causing University of California - MSDS System PAGE 10 05/03/96 palpitations, extrasystole, tachycardia, or other arrhythmias, which may progress to irreversible myocardial fibrosis and circulatory failure. ethyl alcohol has been clearly demonstrated to cause reproductive effects. The newborns of alcoholic mothers may exhibit fetal alcohol syndrome with low birth weights, prominence of the forehead and mandible, cleft palate, maxillary hypoplasia, short palpebral fissures, microphthalmia, epicanthal folds, severe growth retardation, mental retardation, microcephaly, cardiac anomalies, and possibly malorientation of the brain. 9 newborns of a high risk group, that is women who drink more than 2 ounces per day, showed increased tremors and non-alert wake states and decreased vigorous activity. Reproductive effects have also been reported in animals. Human consumption of alcoholic beverages has been causally related to the occurrence of malignant tumors of the oral cavity, pharynx, larynx, esophagus and liver. METHYL ALCOHOL (METHANOL): NARCOTIC/NEUROTOXIN. ACUTE EXPOSURE- May cause mild and transient inebriation and subsequent drowsiness followed by an asymptomatic period lasting 8-48 hours. Following the delay, coughing, dyspnea, headache, dullness, weakness, vertigo or dizziness, nausea, vomiting, occasional diarrhea, anorexia, violent pain in the back, abdomen, and extremities, restlessness, apathy or delirium, and rarely, excitement and mania may occur. Rapid, shallow respiration due to metabolic acidosis, cold and clammy skin, hypotension, cyanosis, opisthotonos, convulsions, mild tachycardia, cardiac depression, peripheral neuritis, cerebral and pulmonary edema, unconsciousness, and coma are possible. Effects on the eye may include optic neuritis, blurred or dimmed vision, dilated, unresponsive pupils, ptosis, eye pain, concentric constriction of visual fields, diplopia, change in color perception, photophobia, and optic nerve atrophy. Partial blindness or possibly delayed transient or permanent blindness may occur. Bilateral sensorineural deafness has been reported in a single case. Liver, kidney, heart, stomach, intest inal and pancreatic damage may also occur. Death may be due to respiratory failure or rarely from circulatory collapse. As little as 15 ml has caused blindness; the usual fatal dose is 60-240 ml. Prolonged asthenia and irreversible effects on the nervous system including difficulty in speech, motor dysfunction with rigidity, spasticity, and hypokinesis have been reported. CHRONIC EXPOSURE- Repeated ingestion may cause visual impairment and blindness and other systemic effects as detailed in acute ingestion. Reproductive effects have been reported in animals. METHYL ISOBUTYL KETONE: NARCOTIC. ACUTE EXPOSURE- May cause coughing, gastroenteritis, and central nervous system depression with headache, dizziness, dullness and vomiting. CHRONIC EXPOSURE- No data available. ETHYL ACETATE: NARCOTIC. ACUTE EXPOSURE- Ingestion of small amounts may cause sore throat, abdominal pain, and diarrhea. Large amounts may cause central nervous system depression, with dizziness, headache, weakness, fatigue, drowsiness, and unconsciousness. Poisoning may cause congestion of the liver and kidneys. CHRONIC EXPOSURE- Animals fed 1000 mg/kg for 1 month showed no effects. University of California - MSDS System PAGE 11 05/03/96 FIRST AID- Qualified medical personnel should consider the following: Perform gastric lavage. If this can not be done immediately, proceed with the following: Induce emesis with syrup of ipecac and water. When vomiting occurs, keep head lower than hips to help prevent aspiration. Do not give anything by mouth or induce vomiting if person is unconscious or otherwise unable to swallow. Treat symptomatically and supportively. Get medical attention immediately. ANTIDOTE: The following antidote has been recommended. However, the decision as to whether the severity of poisoning requires administration of any antidote and actual dose required should be made by qualified medical personnel. ETHANOL POISONING: Naloxone, 0.01 mg/kg, intravenously, has an arousal effect in acute alcoholic coma (Dreisbach, Handbook of Poisoning, 11th Ed.). Antidote should be administered by qualified medical personnel. ------------------------------------------------------------------------------ REACTIVITY REACTIVITY: Stable under normal temperatures and pressures. INCOMPATIBILITIES: ETHYL ALCOHOL (ETHANOL): ACETIC ANHYDRIDE AND SODIUM HYDROGEN SULFATE: Possible explosion. ACETYL CHLORIDE: Violent reaction. ACETYL BROMIDE: Violent reaction. ALKALI METALS: Liberates flammable hydrogen gas. ALUMINUM SESQUIBROMIDE ETHYLATE: Explosion. AMMONIUM HYDROXIDE AND SILVER (I) OXIDE: Formation of explosive silver nitride. BARIUM PERCHLORATE: Formation of explosive compound. BROMINE PENTAFLUORIDE: Ignition and explosions are possible. CALCIUM HYPOCHLORITE: Possible explosion. CHLORINE TRIOXIDE: Violent reaction. CHLORYL PERCHLORATE: Possible ignition. CHROMIC ANHYDRIDE: Ignition. CHROMIUM TRIOXIDE: Possible ignition. CHROMYL CHLORIDE: Ignition. DIOXYGEN DIFLUORIDE: Possible explosion. DISULFURIC ACID AND NITRIC ACID: Possible ignition. DISULFURYL DIFLUORIDE: Violent reaction. FLUORINE NITRATE: Explosion. HYDROGEN PEROXIDE: Formation of highly explosive shock-sensitive compound. HYDROGEN PEROXIDE-SULFURIC ACID MIXTURE: Explosion. IODINE HEPTAFLUORIDE: Ignition. IODINE-MERCURIC OXIDE-METHYL ALCOHOL MIXTURE: Possible explosion. IODINE AND PHOSPHORUS: Formation of explosive ethane iodide. MANGANESE PERCHLORATE AND 2,2-DIMETHOXY PROPANE: Possible explosion. MERCURIC NITRATE: Formation of explosive compound. NITRIC ACID: Violent reaction. NITROSYL PERCHLORATE: Possible explosion. OXIDIZERS (STRONG): Fire and explosion hazard. University of California - MSDS System PAGE 12 05/03/96 PERCHLORATES: May form explosive compound when mixed. PERCHLORIC ACID: Explosion. PERMANGANIC ACID: Ignition or explosion. PERMANGANATES AND SULFURIC ACID: Explosion. PEROXYDISULFURIC ACID: Possible explosion. PHOSPHORUS(III) OXIDE: Ignition. PLATINUM: Ignition. POTASSIUM: Violent reaction. POTASSIUM DIOXIDE: Violent reaction, possible explosion. POTASSIUM PERCHLORATE: Possible explosion. POTASSIUM PERMANGANATE: Possible explosion. POTASSIUM TERT-BUTOXIDE: Ignition. RUTHENIUM(VIII) OXIDE: Formation of explosive compound. SILVER AND NITRIC ACID: Formation of explosive compound. SILVER NITRATE: Formation of explosive compound. SILVER PERCHLORATE: May form explosive compound when mixed. SODIUM-AIR: Possible explosion. SODIUM HYDRAZIDE: May cause violent explosion on contact. SODIUM PEROXIDE: Violent reaction. SULFURIC ACID AND SODIUM DICHROMATE: Possible explosion. TETRACHLOROSILANE: Violent reaction. URANIUM HEXAFLUORIDE: Violent reaction. URANYL PERCHLORATE: May form explosive compound when mixed. See also alcohols. METHYL ALCOHOL (METHANOL): ACETYL BROMIDE: Violent reaction with formation of hydrogen bromide. ALKYLALUMINUM SOLUTIONS: Violent reaction. ALUMINUM: Corrodes. BARIUM PERCHLORATE: Distillation yields highly explosive alkyl perchlorate. BERYLLIUM HYDRIDE: Violent reaction, even at -196 C. BROMINE: Vigorously exothermic reaction. CALCIUM CARBIDE: Violent reaction. CHLORINE: Possible ignition and explosion hazard. CHLOROFORM AND SODIUM HYDROXIDE: Explosive reaction. CHROMIUM TRIOXIDE (CHROMIC ANHYDRIDE): Possible ignition. CYANURIC CHLORIDE: Violent reaction. DICHLOROMETHANE: Possible ignition and explosion. DIETHYL ZINC: Possible ignition and explosion. HYDROGEN PEROXIDE + WATER: Explosion hazard. IODINE + ETHANOL + MERCURIC OXIDE: Explosion hazard. LEAD: Corrodes. LEAD PERCHLORATE: Explosion hazard. MAGNESIUM: Violent reaction. MAGNESIUM (POWDERED): Mixtures are capable of detonation. METALS: Incompatible. NICKEL: Possible ignition in the presence of nickel catalyst. NITRIC ACID (CONCENTRATED): Mixtures of greater than 25% acid may decompose violently. OXIDIZERS (STRONG): Fire and explosion hazard. PERCHLORIC ACID: Explosion hazard. PHOSPHOROUS TRIOXIDE: Possible violent reaction and ignition. PLASTICS, RUBBER, COATINGS: May be attacked. POTASSIUM: Possible dangerous reaction. POTASSIUM HYDROXIDE + CHLOROFORM: Exothermic reaction. POTASSIUM TERT-BUTOXIDE: Fire and explosion hazard. University of California - MSDS System PAGE 13 05/03/96 SODIUM + CHLOROFORM: Possible explosion. SODIUM HYPOCHLORITE: Explosion hazard. SODIUM METHOXIDE + CHLOROFORM: Violent reaction. SULFURIC ACID: Fire and explosion hazard. ZINC: Explosion hazard. METHYL ISOBUTYL KETONE: ALDEHYDES: Incompatible. NITRIC ACID: Incompatible. OXIDIZERS (STRONG): Fire and explosion hazard. PERCHLORIC ACID: Incompatible. PLASTICS, RUBBER AND RESINS: May be attacked. POTASSIUM-TERT-BUTOXIDE: Ignites on contact. REDUCING MATERIALS: Vigorous reaction. ETHYL ACETATE: ACIDS (STRONG): Exothermic decomposition. BASES (STRONG): Exothermic decomposition. CHLOROSULFONIC ACID: Exothermic decomposition. LITHIUM TETRAHYDROALUMINATE: Possible explosion. NITRATES: Fire and explosion hazard. OLEUM: Exothermic decomposition. OXIDIZERS (STRONG): Fire and explosion hazard. POTASSIUM TERT-BUTOXIDE: Possible ignition. DECOMPOSITION: Thermal decomposition products may include toxic and hazardous fumes of formaldehyde and oxides of carbon. POLYMERIZATION: Hazardous polymerization has not been reported to occur under normal temperatures and pressures. ------------------------------------------------------------------------------ STORAGE AND DISPOSAL Observe all federal, state and local regulations when storing or disposing of this substance. **Storage** Store in accordance with 29 CFR 1910.106. Bonding and grounding: Substances with low electroconductivity, which may be ignited by electrostatic sparks, should be stored in containers which meet the bonding and grounding guidelines specified in NFPA 77-1983, Recommended Practice on Static Electricity. Store away from incompatible substances. **Disposal** Disposal must be in accordance with standards applicable to generators of hazardous waste, 40 CFR 262. EPA Hazardous Waste Number D001. University of California - MSDS System PAGE 14 05/03/96 100 pound CERCLA Section 103 Reportable Quantity. ------------------------------------------------------------------------------ CONDITIONS TO AVOID Avoid contact with heat, sparks, flames or other ignition sources. Vapors may be explosive. Material is poisonous; avoid inhalation of vapors or contact with skin. Do not allow material to contaminate water sources. ------------------------------------------------------------------------------ SPILL AND LEAK PROCEDURES OCCUPATIONAL SPILL: Shut off ignition sources. Do not touch spilled material. Stop leak if you can do it without risk. Use water spray to reduce vapors. For small spills, take up with sand or other absorbent material and place into containers for later disposal. For larger spills, dike far ahead of spill for later disposal. No smoking, flames or flares in hazard area! Keep unnecessary people away; isolate hazard area and deny entry. Reportable Quantity (RQ): The Superfund Amendments and Reauthorization Act (SARA) Section 304 requires that a release equal to or greater than the reportable quantity established for that substance be immediately reported to the local emergency planning committee and the state emergency response commission (40 CFR 355.40). If the release of this substance is reportable under CERCLA Section 103, the National Response Center must be notified immediately at (800) 424-8802 or (202) 426-2675 in the metropolitan Washington, D.C. area (40 CFR 302.6). ------------------------------------------------------------------------------ PROTECTIVE EQUIPMENT VENTILATION: Provide local exhaust ventilation and/or general dilution ventilation to meet published exposure limits. RESPIRATOR: The following respirators are recommended based on information found in the physical data, toxicity and health effects sections. They are ranked in order from minimum to maximum respiratory protection. The specific respirator selected must be based on contamination levels found in the work place, must be based on the specific operation, must not exceed the working limits of the respirator and must be jointly approved by the National Institute for Occupational Safety and Health and the Mine Safety and Health Administration (NIOSH-MSHA). Any type 'C' supplied-air respirator with a full facepiece operated in pressure-demand or other positive pressure mode or with a full facepiece, helmet or hood operated in continuous-flow mode. Any self-contained breathing apparatus with a full facepiece operated in pressure-demand or other positive pressure mode. FOR FIREFIGHTING AND OTHER IMMEDIATELY DANGEROUS TO LIFE OR HEALTH CONDITIONS: University of California - MSDS System PAGE 15 05/03/96 Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode. Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained breathing apparatus operated in pressure-demand or other positive-pressure mode. CLOTHING: Employee must wear appropriate protective (impervious) clothing and equipment to prevent repeated or prolonged skin contact with this substance. GLOVES: Employee must wear appropriate protective gloves to prevent contact with this substance. EYE PROTECTION: Employee must wear splash-proof or dust-resistant safety goggles to prevent eye contact with this substance. Emergency eye wash: Where there is any possibility that an employee's eyes may be exposed to this substance, the employer should provide an eye wash fountain within the immediate work area for emergency use. ------------------------------------------------------------------------------ COPYRIGHT 1984-1995 MDL INFORMATION SYSTEMS, INC. ALL RIGHTS RESERVED. CREATION DATE: 11/14/85 REVISION DATE: 07/01/95 -ADDITIONAL INFORMATION- THE ABOVE INFORMATION IS BELIEVED TO BE ACCURATE AND REPRESENTS THE BEST INFORMATION CURRENTLY AVAILABLE TO US. HOWEVER, WE MAKE NO WARRANTY OF MERCHANTABILITY OR ANY OTHER WARRANTY, EXPRESSED OR IMPLIED, WITH RESPECT TO SUCH INFORMATION, AND WE ASSUME NO LIABILITY RESULTING FROM ITS USE. USERS SHOULD MAKE THEIR OWN INVESTIGATIONS TO DETERMINE THE SUITABILITY OF THE INFORMATION FOR THEIR PARTICULAR PURPOSES.